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肿瘤是一种以细胞增殖失控为特点的疾病。细胞周期蛋白依赖性激酶４（ＣＤＫ４）的抑制因子Ｐ１６蛋白是１９９３年发现的第一种直接作用于细胞周期，抑制细胞分裂的抑癌蛋白［１］，成为肿瘤研究领域又一引人注目的分子。我们首次利用中山大学生命科学院王 章教授［２］构建
Tumors are a disorder characterized by uncontrolled cell proliferation. Inhibitor of Cyclin-Dependent Kinase 4 (CDK4) P16 protein is the first tumor suppressor protein that was found in 1993 to act directly on the cell cycle and inhibit cell division [1], becoming another attractive area in oncology research molecular. For the first time, we use Professor Wang Zhang from Sun Yat-sen University of Life Sciences [2] to construct