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自Heinz Otto Schild提出组胺受体存在H_1和H_2亚型以来,许多器官,尤其是脑内组胺受体亚型的生理及药理研究取得了重要进展。 一、脑内组胺受体的存在 组胺不能直接通过血脑屏障,因此中枢神经组胺受体的作用是调节脑内胺类递质的效应,这些胺类是局部合成,贮存和释放。十多年前已证明,脑内有神经元和肥大细胞含有组胺,这主要是通过神经化
Since Heinz Otto Schild proposed the histamine receptors exist in H_1 and H_2 subtypes, many organs, especially the histamine receptor subtypes of the brain physiological and pharmacological research has made important progress. First, the presence of histamine receptors in the brain Histamine can not directly through the blood-brain barrier, so the role of central nervous histamine receptors is to regulate the effects of amine neurotransmitters in the brain, these amines are synthesized locally, storage and release. More than a decade ago it has been shown that neurons and mast cells in the brain contain histamine, mainly through neurogenesis