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用妊娠2、4和6天的大鼠,按妊娠期各分为实验组与对照组。实验组向一侧子宫角内注射0.1ml醋酸棉酚注射液(含棉酚0.5mg或1mg),对照组向一侧子宫角内注射0.1ml生理盐水。于妊娠12～13天处死动物,观察两组动物双侧子宫角内胚胎存活情况。结果表明实验组动物无论妊娠2、4、6天,注射1mg棉酚侧子宫角内的胚胎死亡率皆明显高于未注射侧;而对照组动物注射盐水侧子宫角内胚胎死亡率与未注射侧比较无显著差异。实验提示棉酚直接宫腔内一次给药可能是用于终止早期妊娠的一种有效药物。
With 2, 4 and 6 days of pregnancy, rats were divided into experimental group and control group according to pregnancy. The experimental group to the side of the uterus injection of 0.1ml acetate gossypol injection (gossypol 0.5mg or 1mg), the control group to the side of the uterus injection of 0.1ml saline. The animals were sacrificed 12 to 13 days after pregnancy, and the survival of bilateral uterine horn embryos in both groups was observed. The results showed that the embryo mortality in the uterine horn of 1 mg gossypol injection group was significantly higher than that of the uninjected side in the experimental group at 2, 4, 6 days of gestation. In the control group, Side no significant difference. Experiments suggest that a single intrauterine gossypol administration may be used to terminate early pregnancy is an effective drug.