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目的:观察奥氮平联合阿扎司琼预防肺癌患者因化疗所致恶心呕吐的临床效果。方法:60例肺癌患者并按随机数字表法分为对照组和观察组(每组各30例),两组患者均在化疗前30 min给予阿扎司琼静滴,观察组在此基础上给予奥氮平片口服,观察两组患者化疗前后恶心、呕吐和食欲减退情况。结果:观察组患者在化疗后的第1天和第2-7天,恶心、呕吐的程度均较对照组轻(P<0.05),即奥氮平联合阿扎司琼对化疗引起的急性呕吐和迟发型呕吐均有较好的缓解作用;两组患者化疗前的KPS得分无明显差异,而经过1周的化疗后,两组患者的KPS得分均降低,但对照组较观察组降低的更为明显(P<0.05);化疗前两组患者的外周血象、肝肾功能指标水平无明显差异,而化疗后,两组患者的上述指标水平均异常,但对照组较观察组更为明显。结论:奥氮平联合阿扎司琼对肺癌化疗患者的急性和迟发性恶心、呕吐均有较好的缓解作用,且毒副作用小,可促进肺癌化疗患者生活质量的提高。
Objective: To observe the clinical efficacy of olanzapine combined with azasetron in the prevention of chemotherapy-induced nausea and vomiting in patients with lung cancer. Methods: Sixty patients with lung cancer were randomly divided into control group and observation group (30 cases in each group) according to random number table. Patients in both groups received intravenous infusion of atazanan 30 min before chemotherapy. On the basis of this, Olanzapine tablets were given orally, and the nausea, vomiting and loss of appetite were observed before and after chemotherapy in both groups. Results: In the observation group, on the first day and 2-7 days after chemotherapy, the degree of nausea and vomiting was lower in the observation group than in the control group (P <0.05), that is, the omeprazole combined with atazan on the acute vomiting induced by chemotherapy And late-onset vomiting have a good relief; two groups of patients before chemotherapy KPS score no significant difference, and after a week of chemotherapy, KPS scores decreased in both groups, but the control group decreased more than the observation group (P <0.05). There was no significant difference in peripheral blood and liver and kidney function before and after chemotherapy. After chemotherapy, the above indexes were abnormal in both groups, but the control group was more obvious than the observation group. Conclusion: Olanzapine combined with atazan plays a good alleviating effect on acute and delayed nausea and vomiting in patients with lung cancer chemotherapy. The side effects of olanzapine combined with azaserine are small, which can promote the quality of life of patients with lung cancer chemotherapy.