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多发性肌炎(皮肌炎)认为是一种自身免疫性疾病,过去曾经用鞣酸化红细胞凝集法、琼脂胶扩散法、免疫荧光法等以证明有对于肌肉组织的自身抗体,但均未获肯定的结果。本文报告用敏感的被动血凝法测定抗纯化的肌红蛋白抗体,对多发性肌炎、重症肌无力、进行性肌营养不良症、类风湿性关节炎、进行性系统性硬皮症、系统性红斑狼疮、风湿热和对照组进行了测定。31例多发性肌炎中22例(71％)阳性,较重症肌无力13例中4例(31％)的阳性率明显为高(P<0.02),亦明显地高于Duchenne型肌营养不良症和其它疾病(P<0.01)。对照组38例中,无1例阳性。而且抗体滴定度亦以多发性肌炎为高。多发性肌炎病人中,是否有皮肤损害、或合并有系统性红斑狼疮和进行性
Polymyositis (dermatomyositis) is considered to be an autoimmune disease. In the past, autoantibodies to muscle tissue have been demonstrated by tanning erythrocyte agglutination, agar gel diffusion, immunofluorescence and the like, but none have been obtained Positive result. This article reports the detection of anti-purified myoglobin antibodies by sensitive passive coagulation assays for the treatment of polymyositis, myasthenia gravis, progressive muscular dystrophy, rheumatoid arthritis, progressive systemic sclerosis, systemic Lupus erythematosus, rheumatic fever and control group were measured. Of the 31 cases with polymyositis, 22 (71%) were positive and 4 (31%) of 13 cases were significantly higher (P <0.02) than those with Duchenne muscular dystrophy Disease and other diseases (P <0.01). In the control group of 38 cases, none of them was positive. And antibody titer also polymyositis is high. Polymyositis patients, whether there is skin damage, or combined with systemic lupus erythematosus and progressive