规律腹腔注射海洛因建立♂大白鼠海洛因身体依赖模型（ｎ＝１５），戒断后制成戒断模型（ｎ＝１０），并设对照组。对依赖组和戒断组大鼠的大脑、下丘脑、垂体、肾上腺、睾丸和附睾组织做光镜和电镜观察，结果发现依赖组的大脑皮质、下丘脑、垂体、睾丸和附睾均有明显的组织病理改变及超微结构改变，且短期戒断后这些改变仍持续存在。该文对海洛因依赖引起中枢神经系统及下丘脑－垂体－睾丸轴组织产生病理改变的机理作了探讨。 Regular intraperitoneal injection of heroin was used to establish heroin dependence model (n = 15) in rats. After withdrawal, heroin withdrawal models (n = 10) were established and the control group was established. The brain, hypothalamus, pituitary, adrenal, testis and epididymis of the dependent group and the withdrawal group were observed under light microscope and electron microscope. The results showed that the cerebral cortex, hypothalamus, pituitary, testis and epididymis of the dependent group had obvious Histopathological changes and ultrastructural changes, and these changes persist after short-term withdrawal. This article explores the mechanism of heroin dependence in the central nervous system and hypothalamic-pituitary-testicular axis pathological changes were discussed.