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目前,体内药物分析在医药科学研究中的作用日益突出.微量体内药物或其它体液成分大都采用现代分析仪器,如GC/MS,HPLC或LC/MS等进行分析,从而使分析灵敏度、专属性大为提高,分析速度越来越快,自动化程度也越来越高.与此同时,对生物体液样品的预处理过程的要求也越来越高.采用毛细管GC或HPLC分析生物体液样品时,样品中蛋白质等生物大分子及其它内源性物质对待测药物分子可产生明显的干扰,前者还可使色谱系统严重污染、损坏或堵塞GC或HPLC的柱子,大大缩短柱寿命,同时也影响分析结果的准确性.因此,供体内药物分析的生物体液样品
At present, the role of in vivo drug analysis in medical scientific research is increasingly prominent.Micro-body drugs or other body fluid components are mostly analyzed by modern analytical instruments such as GC / MS, HPLC or LC / MS to make the analysis sensitivity and specificity large In order to improve, the speed of analysis is faster and faster, and the degree of automation is also higher and higher, meanwhile, the requirements for pretreatment of biological fluid samples are also higher and higher.When using capillary GC or HPLC to analyze biological fluid samples, Protein and other biological macromolecules and other endogenous substances on the test drug molecules can produce significant interference, the former can make the chromatographic system seriously contaminated, damaged or blocked GC or HPLC column, greatly shorten the column life, but also affect the analysis results Therefore, for in vivo drug analysis of biological fluid samples