论文部分内容阅读
目的:探讨急性冠状动脉综合征(ACS)患者血清中介素(IMD)水平及临床意义。方法:选取ACS患者55例(ACS组),健康对照组30例,采用酶联免疫吸附试验检测血清IMD、超敏-C反应蛋白(hs-CRP)水平。依据冠脉造影结果评估冠脉狭窄程度,以Gensini积分总和表示。采用Pearson相关分析方法分析血清IMD水平与冠脉狭窄程度的相关性。结果:ACS组血清IMD、hs-CRP水平显著高于对照组(均P<0.01),血清IMD与Gensini积分正相关(r=0.872,P<0.01),ACS组血清IMD与hs-CRP呈正相关(r=0.650,P<0.01)。结论:ACS患者血清IMD水平升高,其水平与冠脉病变严重程度有关,IMD可能通过抗炎症发挥心肌保护作用,或可成为ACS诊断与危险评估有价值的生物标志物。
Objective: To investigate the serum level of interleukin (IMD) in patients with acute coronary syndrome (ACS) and its clinical significance. Methods: Fifty-five ACS patients (ACS group) and 30 healthy controls were enrolled in this study. The levels of serum IMD and hs-CRP were detected by enzyme linked immunosorbent assay (ELISA). Coronary angiography based on the results of assessing the degree of coronary stenosis, Gensini points sum. Pearson correlation analysis was used to analyze the correlation between serum IMD level and coronary artery stenosis. Results: Serum levels of IMD and hs-CRP in ACS group were significantly higher than those in control group (all P <0.01). Serum IMD was positively correlated with Gensini score (r = 0.872, P <0.01) (r = 0.650, P <0.01). CONCLUSIONS: Serum IMD levels are elevated in patients with ACS and their levels are related to the severity of coronary artery disease. IMD may exert myocardial protective effects through anti-inflammatory or may be a valuable biomarker for ACS diagnosis and risk assessment.