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目的:探讨幽门螺杆菌(H.pylori)感染和儿童慢性特发性血小板减少性紫癜(ITP)的相关性分析。方法:在2009至2011年,对360例健康儿童和360例慢性ITP患儿进行H.pylori感染检验,比较其H.pylori感染阳性率。将80例H.pylori感染阳性的慢性ITP患儿随机分为对照组和实验组各40人。对照组采用激素治疗,实验组采用抗幽门螺杆菌和激素联合治疗。结果:健康儿童H.pylori感染阳性40例,阳性率11.11%,慢性ITP患儿感染81例,阳性率22.5%。ITP患儿H.pylori感染阳性率高于健康儿童,2组H.pylori感染阳性率相比差异显著(P<0.05)。实验组患儿治疗后1、2、3个月的的血小板计数明显高于对照组,血小板相关免疫球蛋白低于对照组,差异显著(P<0.05)。实验组治疗总有效率高于对照组,差异显著(P<0.05)。实验组6个月内和6个月后的复发率均低于对照组,总复发率也低于对照组,差异显著(P<0.05)。结论:在慢性特发性血小板减少性紫癜患儿中幽门螺杆菌感染率要显著高于正常儿童,对慢性ITP患儿进行抗H.pylori感染治疗可以有效提高血小板计数,降低血小板相关免疫球蛋白,减少复发率,值得在临床上推广。
Objective: To investigate the correlation between H.pylori infection and chronic idiopathic thrombocytopenic purpura (ITP) in children. Methods: Between 2009 and 2011, 360 healthy children and 360 chronic ITP children were tested for H.pylori infection, and the positive rate of H.pylori infection was compared. Eighty chronic H. pylori-positive children with chronic ITP were randomly divided into control group and experimental group with 40 in each. The control group with hormone therapy, experimental group with anti-Helicobacter pylori and hormone combination therapy. Results: There were 40 positive cases of H.pylori infection in healthy children, the positive rate was 11.11%. 81 cases were infected with chronic ITP, the positive rate was 22.5%. The positive rate of H.pylori infection in children with ITP was higher than that in healthy children, and the positive rate of H.pylori infection in two groups was significantly different (P <0.05). The platelet count of experimental group was significantly higher than that of control group at 1, 2 and 3 months after treatment, and the relative immunoglobulin of platelet was lower than that of control group (P <0.05). The total effective rate of experimental group was higher than that of control group, with significant difference (P <0.05). The recurrence rates of the experimental group within 6 months and 6 months were lower than that of the control group, and the total recurrence rate was also lower than that of the control group (P <0.05). Conclusion: The infection rate of Helicobacter pylori in children with chronic idiopathic thrombocytopenic purpura is significantly higher than that of normal children. Treatment of chronic ITP children with anti-H.pylori infection can effectively increase the platelet count and the platelet-associated immunoglobulin , Reduce the recurrence rate, it is worth in the clinical promotion.