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目的评价雷帕霉素洗脱支架(CypherTM)与紫杉醇涂层支架(Taxus ExpressTM)治疗冠状动脉复杂病变(B2／C型病变)的近期和远期疗效。方法入选本研究267例,男性占68％,糖尿病占38．5％。雷帕霉素洗脱支架组169例,共植入雷帕霉素洗脱支架172条;紫杉醇涂层支架组98例,植入紫杉醇涂层支架165条。观察6个月的主要心血管事件。结果两组的临床特征相似。支架植入成功率100％,95％的病人完成6个月的随访。主要心血管事件发生率:雷帕霉素洗脱支架组5．9％(10／169),紫杉醇涂层支架组9．2％(9／98),两组差异无统计学意义(X2=1．001,P=0．317)。结论雷帕霉素洗脱支架治疗冠状动脉复杂病变疗效和安全性与紫杉醇涂层支架相似。
Objective To evaluate the short-term and long-term efficacy of the combination of CypherTM and Taxus ExpressTM in the treatment of complicated coronary artery disease (type B2 / C lesions). Methods The study was enrolled in 267 cases, 68% of men and 38.5% of diabetes. A total of 169 rapamycin-eluting stents were implanted with 172 rapamycin-eluting stents. Paclitaxel-eluting stents (98 cases) were implanted with paclitaxel-coated stents. Six months of major cardiovascular events were observed. Results The clinical characteristics of both groups were similar. Stent implantation success rate of 100%, 95% of patients completed 6 months follow-up. The incidence of major cardiovascular events was 5.9% (10/169) in the rapamycin-eluting stent group and 9.2% (9/98) in the paclitaxel-coated stent group, with no significant difference between the two groups (X2 = 1.001, P = 0.317). Conclusion The efficacy and safety of rapamycin-eluting stent in the treatment of complicated coronary artery lesions are similar to paclitaxel-coated stent.