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本研究采用饲菌复合失血性休克造成家兔MSOF的实验模型,利用放射配基结合分析法观察了脏器衰竭后24及96小时肝肺组织中β肾上腺素能受体数量和亲和力的改变,并用生化方法监测了同时间点血液及组织中磷酯酶A_2活性的变化。结果表明:家兔出现MSOF后24小时肝组织β受体数量和亲和力变化不大,肺组织β受体数量下降,亲和力不变。MSOF后96小时肝肺β受体数量和亲和力均明显增加。家兔出现MSOF后24及96小时血液及组织中磷酯酶A_2活性逐渐增强,提示β受体的变化及磷酯酶A_2激活在MSOF早晚期病理损伤中起一定作用。
In this study, rabbit MSOF was induced by feeding combined hemorrhagic shock in rabbits. The changes of the number and affinity of β-adrenoceptors in liver and lung tissues at 24 and 96 hours after organ failure were observed by radioligand binding assay. The biochemical methods were used to monitor the changes of phospholipase A 2 activity in blood and tissues at the same time point. The results showed that there was no significant change in the number and affinity of β receptors in liver tissue 24 h after MSOF, the number of β receptors in lung tissue decreased, and the affinity remained unchanged. 96 hours after MSOF hepatic β receptor number and affinity were significantly increased. Twenty-four and ninety-six hours after MSOF, the phospholipase A 2 activity in blood and tissues gradually increased, suggesting that the changes of β receptors and the activation of phosphatase A 2 play a role in the early and late MSOF pathological injury.