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目的探讨肺部孤立性纤维瘤的临床特点、早期诊断及外科治疗方法。方法回顾性分析28例肺巨大孤立性纤维瘤病例资料、术后切除组织常规病理及免疫组织化学检查情况,并进行术后随访。结果 28例中术后病理免疫组织化学显示,CD34阳性24例,CD99阳性16例,波形蛋白Vimentin阳性19例,Bcl-2阳性6例,另4例SMA阳性,3例Actin阳性表达。术后21例生存,未见肿块复发,1例死于心肌梗死,6例失访。结论肺孤立性纤维瘤早期临床表现无特异性,手术治疗是目前首选治疗方式,且术后预后较好。
Objective To investigate the clinical features, early diagnosis and surgical treatment of solitary pulmonary fibroids. Methods A retrospective analysis of 28 cases of pulmonary solitary fibromatosis data, postoperative surgical removal of histopathological and immunohistochemical examination, and follow-up. Results The postoperative pathological immunohistochemistry showed that 24 cases were positive for CD34, 16 were CD99 positive, 19 cases were vimentin positive, 6 cases were positive for Bcl-2, 4 cases were positive for SMA and 3 cases were Actin positive. Twenty-one patients survived without recurrence of tumor, one died of myocardial infarction and six were lost to follow-up. Conclusion The early clinical manifestations of pulmonary solitary fibrous tumor are nonspecific. Surgical treatment is the first choice of treatment and the prognosis is good.