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本文主要回顾单克隆抗体(单抗)在治疗中应用的概况,对临床用单抗制剂的质量标准,存在的问题以及解决办法等内容。单抗在治疗中的应用早就受到人们的广泛重视,并且在预防移植排斥反应及治疗肿瘤上已取得了较为满意的效果,在治疗自身免疫性疾病、免疫缺陷病、某些烈性传染病以及解毒中的应用已显示可喜的苗头。但是,为了使单抗在治疗中的应用取得更快的进展,发挥更大的效益,还必须澄清人们的一些模糊认识,解决一些实际问题。
This article reviews the overview of the application of monoclonal antibodies (mAb) in the treatment, the quality standards of clinical monoclonal antibody preparations, problems and solutions. The application of monoclonal antibody in treatment has long been widely regarded by people and it has achieved satisfactory results in the prevention of transplant rejection and tumor treatment. In the treatment of autoimmune diseases, immunodeficiency diseases, certain potent infectious diseases and Detoxification applications have shown encouraging signs. However, in order to make the application of monoclonal antibody in treatment more rapid progress and play more effective, we must also clarify some people’s vague understanding and solve some practical problems.