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目的探讨外周血中CD4+CD25+调节性T细胞在良性前列腺增生症患者治疗前与治疗后的表达情况及意义。方法选取30例良性前列腺增生症患者为观察组,同期体检健康者20例为对照组,检测对照组以及观察组治疗前、后CD4+CD25+调节性T细胞的变化。结果观察组治疗前CD4+CD25+值(10.65±1.47)较对照组(2.41±0.75)升高(P<0.01),治疗后CD4+CD25+值(5.11±2.33)较治疗前降低(P<0.01),但仍高于对照组(P<0.01)。结论外周血CD4+CD25+调节性T淋巴细胞变化对良性前列腺增生症的诊断和治疗有一定价值。
Objective To investigate the expression and significance of CD4 + CD25 + regulatory T cells in peripheral blood before and after treatment of benign prostatic hyperplasia patients. Methods Thirty patients with benign prostatic hyperplasia were selected as observation group and 20 healthy subjects were selected as control group in the same period. The changes of CD4 + CD25 + regulatory T cells in control group and observation group before and after treatment were detected. Results The CD4 + CD25 + value in the observation group before treatment was significantly higher than that in the control group (10.65 ± 1.47 vs. 2.41 ± 0.75, P <0.01), and the CD4 + CD25 + value (5.11 ± 2.33) , But still higher than the control group (P <0.01). Conclusion The changes of CD4 + CD25 + regulatory T lymphocytes in peripheral blood have some value in the diagnosis and treatment of benign prostatic hyperplasia.