目的:探讨急性病毒性感染患者血清C反应蛋白(CRP)、肿瘤坏死因子相关凋亡诱导配体(TRAIL)表达变化及临床诊治指导价值。方法:前瞻性选取湖南省脑科医院2018年3月至2019年6月收治的83例急性病毒性感染患者作为观察组，另取同期收治的81例急性细菌性感染患者作为对照A组，81例健康体检者作为对照B组。入院或体检当日均抽取外周静脉血，离心取血清检测CRP、TRAIL水平，对比3组血清CRP、TRAIL水平，并分析不同治疗效果CRP、TRAIL血清水平，分析血清CRP、TRAIL对急性病毒性感染诊断的应用价值。结果:观察组血清CRP水平低于对照A组，高于对照B组(n P<0.05)；观察组血清TRAIL水平高于对照A组、对照B组(n P<0.05)；血清CRP、TRAIL联合诊断ROC曲线下面积为0.921，高于两者单独诊断(n P<0.05)，CRP截断值为5.664 mg/L、TRAIL截断值为146.82 pg/ml时，联合诊断灵敏度为95.00%，特异度为80.00%；治疗后观察组血清CRP、TRAIL水平较治疗前显著降低(n P<0.05)，且有效者血清CRP、TRAIL水平低于无效者(n P<0.05)。n 结论:血清CRP、TRAIL水平在急性病毒性感染患者疾病鉴别、疗效评估中均具有一定价值，联合检测可显著提高诊断价值，可为临床治疗及预后评估提供可靠参考依据。“,”Objective:To investigate the expression changes of serum C-reactive protein (CRP) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in patients with acute viral infection and the value of clinical diagnosis and treatment.Methods:83 patients with acute viral infection in Hunan Provincial Brain Hospital from March 2018 to June 2019 were selected as the observation group, 81 patients with acute bacterial infection in the same period were selected as the control group A, and 81 healthy people as the control group B for prospective study. On the day of admission or physical examination, peripheral venous blood was drawn; the serum CRP and TRAIL levels were detected. The serum CRP and TRAIL levels of the three groups were compared, and the serum levels of CRP and TRAIL in different treatment groups were analyzed, and the application value of serum CRP and TRAIL in the diagnosis of acute viral infection was analyzed.Results:The serum CRP level of the observation group was lower than that of the control group A, which was higher than that of the control group B (n P<0.05); the serum TRAIL level of the observation group was higher than that of the control group A and B (n P<0.05); the area under the receiver operating characteristic (ROC) curve of the combined diagnosis of serum CRP and TRAIL was 0.921, which was higher than that of the two alone; When the cut-off value of CRP and TRAIL were 5.664 mg/L and 146.82 pg/ml, the combined diagnostic sensitivity was 95.00%, and the specificity was 80.00%; after treatment, the serum CRP and TRAIL levels of the observation group were significantly lower than those before treatment (n P<0.05), and the serum CRP and TRAIL levels of the effective group were lower than those of the ineffective group (n P<0.05).n Conclusions:Serum CRP and TRAIL levels have certain value in the identification and efficacy evaluation of patients with acute viral infection. Combined detection can significantly improve the diagnostic value and provide a reliable reference for clinical treatment and prognosis evaluation.