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目的观察盐酸美金刚治疗帕金森痴呆患者的临床效果。方法选取医院收治的老年帕金森病痴呆患者60例为研究对象,随机分为对照组和观察组,每组30例。对照组采用盐酸多奈哌齐治疗,观察组采用盐酸美金刚治疗,观察2组患者MMSE量表评分与MoCA量表评分、护理前后Barthel指数评分与神经功能缺损评分、护理满意度。结果观察组患者治疗后各时点MMSE量表评分与MoCA量表评分均优于对照组(P<0.05)。心理护理24周后,观察组神经功能缺损评分、Barthel指数评分均优于对照组(P<0.05)。观察组在宣教、环境、态度、操作、治疗效果方面护理满意度均高于对照组(P<0.05)。结论为帕金森痴呆患者提供盐酸美金刚治疗,能够有效改善患者的疾病症状,避免出现严重的不良反应,值得临床推广。
Objective To observe the clinical effect of memantine hydrochloride in patients with Parkinson’s dementia. Methods Sixty elderly patients with Parkinson’s disease who were admitted to hospital were selected as study subjects and randomly divided into control group and observation group, 30 cases in each group. The control group was treated with donepezil hydrochloride, and the observation group was treated with memantine hydrochloride. MMSE scale and MoCA scale scores, Barthel index score and neurological deficit score before and after nursing were observed in two groups, and the nursing satisfaction was also observed. Results The scores of MMSE and MoCA in observation group were better than those in control group at each time point after treatment (P <0.05). After 24 weeks of psychological nursing, the scores of neurological deficit and Barthel index in the observation group were better than those in the control group (P <0.05). The nursing satisfaction of the observation group in the mission, environment, attitude, operation and treatment effect was higher than that of the control group (P <0.05). Conclusions Memantine hydrochloride for patients with Parkinson’s dementia can effectively improve the symptoms of patients and avoid serious adverse reactions, which is worthy of clinical promotion.