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目的比较来曲唑与氯米芬治疗多囊卵巢综合征致不孕症的临床疗效。方法选取东安县妇幼保健院2014年11月—2016年11月收治的多囊卵巢综合征致不孕症患者92例,采用随机数学表法分为对照组和治疗组,各46例。对照组患者给予氯米芬治疗,治疗组患者给予来曲唑治疗。比较两组患者的临床疗效、治疗前后子宫内膜厚度及激素水平[雌二醇(E2)、促黄体生成素(LH)、促卵泡生成素(FSH)]、治疗时间及正常妊娠情况,并观察患者不良反应发生情况。结果治疗组患者治疗总有效率高于对照组(P<0.05)。治疗前,两组患者子宫内膜厚度,E2,LH及FSH水平比较,差异无统计学意义(P>0.05);治疗后,研究组患者子宫内膜厚度大于对照组,E2水平低于对照组,LH及FSH水平高于对照组(P<0.05)。治疗组患者治疗时间短于对照组,妊娠率高于对照组(P<0.05)。治疗组患者不良反应发生率低于对照组(P<0.05)。结论采用来曲唑治疗多囊卵巢综合征致不孕症的临床疗效优于氯米芬,可更有效提高患者妊娠率,缩短治疗时间,且安全性高。
Objective To compare the clinical efficacy of letrozole and clomiphene in the treatment of infertility caused by polycystic ovary syndrome. Methods 92 cases of infertility caused by polycystic ovary syndrome in our hospital from November 2014 to November 2016 were selected and divided into control group and treatment group with 46 cases in each group. Patients in the control group were treated with clomiphene, and patients in the treatment group were given letrozole. The clinical efficacy, endometrial thickness and hormone levels (estradiol (E2), luteinizing hormone (LH) and follicle-stimulating hormone (FSH)] in both groups were compared before and after treatment, and the treatment time and normal pregnancy were compared Observe the occurrence of adverse reactions in patients. Results The total effective rate of treatment group was higher than that of control group (P <0.05). Before treatment, there was no significant difference in endometrial thickness, E2, LH and FSH between the two groups (P> 0.05); after treatment, the thickness of endometrium was higher in the study group than in the control group, and the E2 level was lower than that in the control group , LH and FSH levels were higher than the control group (P <0.05). Treatment group patients shorter treatment time than control group, the pregnancy rate was higher than the control group (P <0.05). The incidence of adverse reactions in the treatment group was lower than that in the control group (P <0.05). Conclusion Letrozole treatment of polycystic ovary syndrome infertility caused by clinical efficacy is superior to clomiphene, can be more effective in improving the pregnancy rate, shorten the treatment time, and high safety.