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目的观察阿托伐他汀联合曲美他嗪治疗不稳定型心绞痛(UA)的疗效。方法将70例确诊为UA的患者随机分为治疗组和对照组。对照组35例,给予常规治疗(硝酸酯类、β-受体阻滞剂或钙离子拮抗剂、抗凝剂及抗血小板药物);治疗组35例,在常规治疗的基础上加用阿托伐他汀和曲美他嗪。观察患者心绞痛的临床症状、心电图变化、硝酸甘油停减情况及血脂变化,并观察药物的不良反应。结果治疗组和对照组临床疗效差异有统计学意义(P<0.05),改善心绞痛患者的缺血心电图(P<0.05),减少硝酸酯类与降低血脂差异有统计学意义(P<0.05)。结论阿托伐他汀联合曲美他嗪治疗不稳定型心绞痛疗效确切。
Objective To observe the efficacy of atorvastatin combined with trimetazidine in the treatment of unstable angina pectoris (UA). Methods Seventy patients diagnosed as UA were randomly divided into treatment group and control group. The control group of 35 patients were given routine treatment (nitrates, β-blockers or calcium antagonists, anticoagulants and antiplatelet drugs); the treatment group of 35 patients on the basis of conventional treatment with Attorney Statin and trimetazidine. Observe the clinical symptoms of patients with angina pectoris, ECG changes, nitroglycerin withdrawal and blood lipid changes, and observe the adverse drug reactions. Results There were significant differences in clinical efficacy between the treatment group and the control group (P <0.05), ischemic electrocardiogram in patients with angina pectoris (P <0.05), and reduction of nitrates and blood lipids (P <0.05). Conclusions Atorvastatin combined with trimetazidine is effective in treating unstable angina pectoris.