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Ghofrani等人进行了一项研究。本研究拟比较三种不同PDE-5抑制剂在肺动脉高压(PAH)患者中对其肺循环和体循环的血液动力学以及气体交换参数的影响。目前的研究已经发现,经典的PDE-5抑制剂西地那非能引起PAH患者的肺血管舒张。伐地那非和他达那非作为新的PDE-5抑制剂,近年来在治
Ghofrani et al. Conducted a study. This study was to compare the effects of three different PDE-5 inhibitors on hemodynamics and gas exchange parameters of the pulmonary and systemic circulation in patients with pulmonary hypertension (PAH). The current study has found that the classic PDE-5 inhibitor sildenafil causes pulmonary vasodilation in PAH patients. Vardenafil and tadalafil have been treated as new PDE-5 inhibitors in recent years