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目的探讨辛伐他汀对骨质疏松症大鼠种植体骨结合的影响。方法将63只Wistar大鼠随机分为正常对照组、单纯去势组、去势加辛伐他汀组3组,通过手术去除双侧卵巢复制大鼠骨质疏松症模型,术后3个月,于每只大鼠左侧股骨处植入1枚种植体,1d后各组分别灌喂生理盐水及辛伐他汀(5mg·kg~(-1)·d~(-1)),术后4、8、12w每组处死5只大鼠,取材制作非脱钙骨磨片,行骨组织形态学观察及骨计量学检测。结果种植12w时,单纯去势组种植体与周围骨组织有一定厚度新骨形成,与种植体接触面积增大。去势加辛伐他汀组和正常对照组种植体周围新生骨组织连接成片且厚度增加,与种植体表面紧密接触。种植术后4、8、12w时,单纯去势组种植体骨结合率(IBCR)、新生骨量(NBV)均明显低于去势加辛伐他汀组和正常对照组,差异有统计学意义(P<0.01);去势加辛伐他汀组IBCR和NBV与正常对照组接近,差异无统计学意义(P>0.05)。结论辛伐他汀能明显增加骨质疏松症大鼠种植体骨结合率及种植体周围新骨形成量。
Objective To investigate the effect of simvastatin on osseointegration of implants in rats with osteoporosis. Methods Sixty-three Wistar rats were randomly divided into normal control group, simple castrate group and castrated plus simvastatin group. The osteoporosis model of bilateral ovary-duplicated rats was removed by surgery. At 3 months after operation, One implant was implanted into the left femur of each rat. After 1 d, saline and simvastatin (5 mg · kg -1 · d -1) , 8,12w each group of 5 rats were sacrificed, drawn non-decalcified bone-refining films, bone morphological observation and bone metrology. Results At 12 weeks of implantation, there was a certain thickness of new bone formation in the implanted group and the surrounding bone tissue, and the contact area with the implants increased. Osteoporosis simvastatin group and normal control group of fresh bone around the implant into a piece and increase the thickness of the implant in close contact with the surface. At 4, 8 and 12 weeks after implantation, the bone incorporation rate (IBCR) and newborn bone mass (NBV) in the castrated group were significantly lower than those in the castrate plus simvastatin group and the normal control group (P <0.01). IBCR and NBV in castrated plus simvastatin group were similar to those in normal control group, with no significant difference (P> 0.05). Conclusion Simvastatin can significantly increase osseointegration of implants and the amount of new bone around implants in osteoporosis rats.