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目的：探讨速激肽与组胺（Ｈｉｓ）反应的关系。方法：观察速激肽受体拮抗剂对豚鼠Ｈｉｓ的整体和离体的呼吸道和心血管效应。结果：单用或合用速激肽ＮＫ－１受体拮抗剂ＣＰ－９６３４５（１ｍｇ·ｋｇ－１，ｉｐ）及ＮＫ－２受体拮抗剂ＳＲ－４８９６８（１ｍｇ·ｋｇ－１，ｉｐ）均可显著降低清醒豚鼠吸入Ｈｉｓ气雾的气道反应性。ＣＰ－９６３４５（１ｍｇ·ｋｇ－１，ｉｖ）可显著降低静脉注射Ｈｉｓ引起麻醉豚鼠支气管和心房的伊文思蓝渗出，ＳＲ－４８９６８（１ｍｇ·ｋｇ－１，ｉｖ）则对肺内压升高有较弱的抑制作用，两药对平均动脉压降低无明显作用。在豚鼠的离体气管和支气管平滑肌标本，ＣＰ－９６３４５（１μｍｏｌ·Ｌ－１）及ＳＲ－４８９６８（１μｍｏｌ·Ｌ－１）对Ｈｉｓ的Ｅｍａｘ及ｐＤ２无明显作用。结论：速激肽部分参与了豚鼠的Ｈｉｓ炎症反应，速激肽受体拮抗剂有抗炎作用。
Objective: To explore the relationship between tachykinin and histamine (His) reaction. Methods: The global and ex vivo respiratory and cardiovascular effects of tachykinin receptor antagonists on guinea pig His were investigated. Results: The NK-1 receptor antagonist CP-96345 (1mg · kg-1, ip) and NK-2 receptor antagonist SR-48968 (1mg · kg-1, ip) Significantly reduces airway responsiveness of awake guinea pigs inhaling His aerosol. CP-96345 (1 mg · kg-1, iv) significantly reduced Evans blue exudation in bronchial and atrium of anesthetized guinea-pigs induced by intravenous injection of His-Propionate (SR-48968) Weak inhibition, the two drugs on the average arterial pressure had no significant effect. In guinea pig tracheal and bronchial smooth muscle specimens, CP-96345 (1μmol·L-1) and SR-48968 (1μmol·L-1) had no significant effect on His Emax and pD2. Conclusion: Tachykinins are partially involved in the His inflammatory response in guinea pigs. Tachykinin receptor antagonists have anti-inflammatory effects.