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Toll样受体(TLRs)是一类能识别微生物,特别是细菌和病毒的模式识别受体,可对病原体相关分子模式进行识别、结合,并引发一系列信号转导,进而导致炎性介质的释放,在天然免疫防御中起着重要作用,并最终激活获得性免疫系统。研究发现,在EB病毒感染时TLRs可以促进B淋巴细胞增殖和活化,从而起到保护宿主的作用。因此,研究并阐明EB病毒激活和抑制TLRs的胞内信号转导途径及机制,对EB病毒相关性疾病的防治具有重要意义。
Toll-like receptors (TLRs) are a class of pattern recognition receptors that recognize microbes, particularly bacteria and viruses, that recognize, bind and trigger molecular patterns of pathogens and trigger a series of signal transduction that leads to the development of inflammatory mediators Release, plays an important role in innate immune defense and ultimately activates the adaptive immune system. The study found that, in the EB virus infection TLRs can promote B lymphocyte proliferation and activation, which play a protective role in the host. Therefore, to study and elucidate the intracellular signal transduction pathway and mechanism of EB virus activation and inhibition of TLRs is of great significance for the prevention and treatment of Epstein-Barr virus-related diseases.