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目的探讨手足口病(Hand-foot-mouth-disease,HFMD)与人体细胞免疫的关系,为临床治疗提供理论依据。方法将在东莞市妇幼保健院儿科就诊的328例HFMD患儿分为普通组和危重组;普通组296例,其中男175例,女121例,平均年龄(2.70±1.44)岁,其中肠道病毒EV71感染67例,柯萨奇A16感染89例;危重组32例,男24例,女8例,平均年龄(2.20±1.31)岁,其中EV71感染24例,柯萨奇病毒A16感染6例;选取门诊体检健康儿童30例为对照组,男18例,女12例,平均年龄(3.78±1.18)岁。采用流式细胞术检测CD3、CD4+、CD8+的表达。结果危重组患儿淋巴细胞CD3(57.63±7.69)、CD4+(34.98±8.59),较对照组CD3(69.67±8.11)、CD4(38.06±8.64)明显降低,危重组患儿CD4+/CD8+(1.18±0.37),较对照组CD4+/CD8+(1.58±0.52)比值降低(t=2.319,2.44,2.41,P均<0.05),差异有统计学意义,HFMD普通组与对照组相比较,差异无统计学意义(P均>0.05)。结论 HFMD危重组患儿存在细胞免疫功能紊乱,对HFMD危重型患儿尽早进行免疫学干预很有必要。
Objective To investigate the relationship between Hand-foot-mouth-disease (HFMD) and human cellular immunity and provide a theoretical basis for clinical treatment. Methods 328 children with HFMD who were treated in Dongguan MCH center were divided into general group and critically ill group. There were 296 normal subjects (175 males and 121 females, mean age 2.70 ± 1.44 years) 67 cases were EV71 infection, 89 cases were Coxsackie A16 infection, 32 cases were critically ill. There were 24 males and 8 females with an average age of (2.20 ± 1.31) years, of which 24 were EV71, 6 were Coxsackie virus A16 ; Outpatient physical examination 30 healthy children as the control group, 18 males and 12 females, mean age (3.78 ± 1.18) years old. Flow cytometry was used to detect the expression of CD3, CD4 + and CD8 +. Results The levels of CD3 (57.63 ± 7.69) and CD4 (34.98 ± 8.59) in the critically ill group were significantly lower than those in the control group (69.67 ± 8.11) and CD4 (38.06 ± 8.64) 0.37). The ratio of CD4 + / CD8 + (1.58 ± 0.52) in control group was lower than that in control group (t = 2.319,2.44,2.41, P <0.05). There was no significant difference between HFMD group and control group Significance (P> 0.05). Conclusions The HFMD critically ill children have cellular immune dysfunction and it is necessary to carry out immunological intervention as soon as possible in HFMD critically ill children.