5-碘尿嘧啶类化合物具有很好的生物学活性,并且是重要医药中间体,方便在5位引入多种基团。为了寻找一个简便有效的嘧啶环5位的碘代方法,我们尝试了碘/二氧化铅,碘/硝酸铈胺和—氯化碘三种方法来进行实验,并对其结果进行了比较,为不同取代类型的尿嘧啶和2-硫尿嘧啶衍生物的碘代方法提供了很好的选择依据。 5-Iodouracil compounds with good biological activity, and is an important pharmaceutical intermediates to facilitate the introduction of a variety of groups in the 5. In order to find a convenient and effective iodine method for the pyrimidine ring at the 5-position, we tried three methods of iodine / lead dioxide, iodine / cerium nitrate and iodine-iodine to carry out the experiment, and compared their results to Different substituted types of uracil and 2-thiouracil derivatives of iodine method provides a good basis for selection.