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转录因子ＧＡＴＡ家族在造血细胞的正常发育中起着重要的作用。利用聚合酶链反应（ＰＣＲ）方法分析了１１６例各种白血病中红系特异转录因子ＧＡＴＡ—１的表达情况。ＡＮＬＬ、ＣＭＬ、Ｃ－ＡＬＬ和ＣＬＬ中的表达率分别为４３．７５％、８８．２４％、１４．２９％和３３．３３％；３例Ｔ－ＡＬＬ均不表达该基因。从８０例ＡＮＬＬ中发现，ＭＯ、Ｍ１和Ｍ２亚型的ＧＡＴＡ－１回表达率较高，而３例Ｍ３型及ＨＬ６０细胞侏均不表达该基因。结果提示ＧＡＴＡ—１基因在多种白血病中的异常表达情况，它在粒单系白血病细胞的持续表达现象，可能与在干细胞或粒单系祖细胞水平的异常增殖、分化和成熟障碍并致白血病有关。
The transcription factor GATA family plays an important role in the normal development of hematopoietic cells. The expression of erythroid-specific transcription factor GATA-1 in 116 leukemia cases was analyzed by polymerase chain reaction (PCR). The expression rates in ANLL, CML, C-ALL, and CLL were 43.75%, 88.24%, 14.29%, and 33.33%, respectively; none of the 3 T-ALLs expressed the gene. From 80 cases of ANLL, the GATA-1 re-expression rate of MO, M1 and M2 subtypes was high, while the 3 M3 and HL60 cells did not express the gene. The results suggest that the GATA-1 gene is aberrantly expressed in a variety of leukemias. Its persistent expression in leukemia cells may be associated with abnormal proliferation, differentiation and maturation at the level of stem cells or progenitor cells of the myeloid leukemia. related.