论文部分内容阅读
目的探讨腹腔镜手术和开腹手术治疗老年良性卵巢肿瘤患者对T细胞亚群及神经内分泌功能的影响。方法选取老年良性卵巢肿瘤患者86例随机分为对照组和观察组各43例,给予对照组患者常规开腹手术治疗,给予观察组患者腹腔镜手术治疗,比较两组患者的手术时间、术中出血量、术后排气时间、住院时间及退热时间,同时比较两组患者治疗前、后T细胞亚群水平、β-内咖啡肽、胰高血糖素及COR等水平变化差异。结果观察组患者术中出血量、术后排气时间、住院时间及退热时间均明显低于对照组,差异有统计学意义(P<0.01);观察组患者治疗后1 d和3 d的CD_3~+水平、CD_4~+水平及CD_4~+/CD_8~+明显高于对照组,β-内咖啡肽、胰高血糖素及COR水平明显低于对照组,差异均有统计学意义(P<0.05)。结论采用腹腔镜手术治疗老年良性卵巢肿瘤能够明显减少患者术中出血量,提高患者预后质量,同时降低手术对患者免疫功能及神经内分泌功能影响,具有更高的手术安全性,值得在临床中推广。
Objective To investigate the effects of laparoscopic surgery and laparotomy on T cell subsets and neuroendocrine function in elderly patients with benign ovarian tumors. Methods Totally 86 elderly patients with benign ovarian tumors were randomly divided into control group and observation group, 43 cases in each group. The patients in control group were given conventional laparotomy, the patients in observation group were treated by laparoscopy. The operation time, Bleeding time, postoperative exhaust time, hospital stay and antipyretic time. The levels of T-cell subsets, β-endocorphin, glucagon and COR were compared between the two groups before and after treatment. Results The bleeding volume, postoperative exhaust time, hospitalization time and antipyretic time in the observation group were significantly lower than those in the control group (P <0.01). In the observation group at 1 and 3 days after treatment The levels of CD_3 ~ +, CD_4 ~ + and CD_4 ~ + / CD_8 ~ + were significantly higher than those of the control group. The levels of β-endocorphin, glucagon and COR were significantly lower than those of the control group <0.05). Conclusion Laparoscopic surgery for benign ovarian tumors in elderly patients can significantly reduce the amount of bleeding and improve the quality of patients with prognosis, while reducing the impact of surgery on the immune function and neuroendocrine function of patients with higher surgical safety, it is worth promoting in the clinic .