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背景:尽管蛋白酶活化受体-1(PAR-1)在体内的作用尚未被完全阐明,但它被认为是人体内主要的凝血酶受体。本研究的目的是明确P A R-1激动剂在人体血管内的直接作用。方法与结果:在局部静脉注射S F L L RN(P A R-1激动剂0.05-15nmol/min)和SLIGKV(PAR-2激动剂1.6-160nmol/min)过程
Background: Although the role of protease-activated receptor-1 (PAR-1) in vivo has not yet been fully elucidated, it is considered to be the major thrombin receptor in the human body. The purpose of this study was to determine the direct role of P A R-1 agonists in human blood vessels. Methods and Results: Intravenous injection of S F L L RN (P R-1 agonist 0.05-15 nmol / min) and SLIGKV (PAR-2 agonist 1.6-160 nmol / min)