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整理和分析血管紧张素Ⅱ对肾小球血管内皮细胞损伤机制的相关文献。以血管紧张素Ⅱ,肾小球血管内皮细胞、内皮细胞损伤等为主题词检索近10年来国内外有关肾小球内皮细胞损伤机制的研究文献,并进行分析。结果发现血管紧张素Ⅱ通过激活炎症反应、氧化应激、诱导细胞凋亡、损伤肾小球血管内皮结构、内分泌功能以及改变肾脏血流动力等途径损伤肾小球血管内皮细胞。本研究对于进一步明确血管紧张素Ⅱ损伤肾小球血管内皮细胞的机制,寻找有效的防治方法具有重要意义。
Collated and analyzed angiotensin Ⅱ on glomerular vascular endothelial cell damage mechanisms related literature. With angiotensin Ⅱ, glomerular vascular endothelial cells, endothelial cell damage as the key words retrieval nearly 10 years of glomerular endothelial cell damage at home and abroad research literature, and analyzed. The results showed that angiotensin Ⅱ can damage glomerular vascular endothelial cells by activating inflammatory response, oxidative stress, inducing cell apoptosis, injuring glomerular vascular endothelial structure, endocrine function and altering renal hemodynamics. This study is to further clarify the mechanism of angiotensin Ⅱ injury of glomerular vascular endothelial cells, to find an effective control method is of great significance.