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目的探讨米力农联合复方丹参注射液治疗慢性心力衰竭急性加重期的疗效。方法选取2012年2月—2014年2月大理市第二人民医院收治的慢性心力衰竭急性加重期患者36例,随机分为观察组和对照组,各18例。对照组在常规治疗基础上给予米力农;观察组在对照组基础上给予复方丹参注射液治疗,5d为1个疗程。比较两组患者的疗效及心功能指标〔最大血流速度E和舒晚期最大血流速度A的比值(E/A)、左室射血分数(LVEF)、左室舒张末内径(LVEDD)、心脏指数(CI)、每搏输出量(SV)〕。结果观察组总有效率高于对照组,差异有统计学意义(P<0.01)。治疗后两组E/A、LVEF、LVEDD、CI、SV比较,差异有统计学意义(P<0.05)。结论米力农联合复方丹参注射液治疗慢性心力衰竭急性加重期的疗效好,不良反应少,安全性高。
Objective To investigate the efficacy of Milrinone combined with Salvia miltiorrhiza injection in the treatment of acute exacerbation of chronic heart failure. Methods Thirty-six patients with acute exacerbation of chronic heart failure admitted to the Second People’s Hospital of Dali City from February 2012 to February 2014 were randomly divided into observation group and control group, with 18 cases in each group. The control group was given Milrinone on the basis of routine treatment. The observation group was given Fufang Danshen injection on the basis of the control group, and a course of treatment was given on the 5th day. The curative effect and cardiac function index (E / A, LVEF, LVEDD, LVEF) of two groups were compared, Heart index (CI), stroke volume (SV)]. Results The total effective rate in the observation group was higher than that in the control group, with significant difference (P <0.01). The difference of E / A, LVEF, LVEDD, CI and SV between the two groups after treatment was statistically significant (P <0.05). Conclusion Milrinone combined with Salvia miltiorrhiza injection in the treatment of acute exacerbation of chronic heart failure with good efficacy, less adverse reactions, high safety.