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目的探讨妊娠期高血压疾病患者血清中脂联素和胎盘生长因子的表达水平及其临床意义。方法采用酶联免疫吸附试验(Enzyme-linked immunosorbent assay,ELISA)测定血脂联素及血清胎盘生长因子的表达水平。结果血清脂联素随病情的加重逐渐降低,且血清脂联素在妊娠期高血压疾病各组之间的表达差异均有统计学意义(P<0.01);血清胎盘生长因子在对照组与妊娠期高血压疾病各组中表达差异有统计学意义(P<0.01);随着病情的发展,血清胎盘生长因子在各组间的表达有所不同:妊娠期高血压组与子痫前期轻度组差异无统计学意义(P>0.05),随病情的加重血胎盘生长因子表达逐渐降低,妊娠期高血压组与子痫前期重度组、子痫前期轻度组与子痫前期重度组比较,差异有统计学意义(P<0.05);妊娠期高血压疾病患者血清脂联素及血清胎盘生长因子的表达均与妊娠期高血压疾病病情轻重呈负相关。结论血清脂联素和胎盘生长因子对妊娠期高血压疾病的防治开辟新的研究路径具有十分重要的理论意义。
Objective To investigate the serum levels of adiponectin and placental growth factor in patients with gestational hypertension and its clinical significance. Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect the expression of adiponectin and serum placental growth factor. Results Serum adiponectin gradually decreased with the severity of the disease and serum adiponectin levels were significantly different between groups (P <0.01). The serum levels of placental growth factor in control group and pregnancy (P <0.01). With the progression of the disease, the expression of serum placental growth factor in different groups was different: the gestational hypertension group and mild preeclampsia There was no significant difference between the two groups (P> 0.05). The expression of blood placental growth factor decreased with the progression of the disease. Compared with the severe preeclampsia group, the gestational hypertension group and the severe preeclampsia group, (P <0.05). The expression of serum adiponectin and serum placental growth factor in patients with gestational hypertension was negatively correlated with the severity of gestational hypertension. Conclusion Serum adiponectin and placental growth factor have a very important theoretical significance for the prevention and treatment of hypertensive disorders in pregnancy.