论文部分内容阅读
探讨对苯二甲酸（ＴＰＡ）作业人群尿液离子水平的变化。方法留取２２４名ＴＰＡ作业工人和１１４名对照组工人当日工前工后尿样。对尿ｐＨ、Ｎａ＋、Ｃｌ－、Ｃａ２＋、ＮＨ４＋、ＰＯ４３－和ＳＯ４２－进行测定分析。结果接触组尿Ｎａ＋、Ｃｌ－、Ｃａ２＋和ＳＯ４２－离子浓度显著高于对照组（Ｐ＜００１），同时ＮＨ４＋与尿ＴＰＡ负荷存在明显的剂量依赖关系；指标聚类分析表明，尿ＴＰＡ水平与尿ＮＨ４＋水平相关系数最大（ｒ＝０２４０５，Ｐ＜００１），提示ＴＰＡ可能是导致尿ＮＨ４＋离子排泄增加的原因。结论由于ＮＨ４＋长期排泄过多，会导致机体负氮平衡，因此似可以尿ＮＨ４＋作为接触ＴＰＡ的早期生物学监测指标。
To investigate the changes of urine ion level in TPA workers. Methods Totally 224 TPA workers and 114 control workers were enrolled in this study. Urine pH, Na +, Cl-, Ca2 +, NH4 +, PO43- and SO42- were measured and analyzed. Results The concentrations of Na +, Cl-, Ca2 + and SO42- in the urine of the exposed group were significantly higher than those of the control group (P <001), and there was a significant dose-dependent relationship between the NH4 + and the urinary TPA load. The index clustering analysis showed that the urinary TPA level And urine NH4 + level had the highest correlation coefficient (r = 0.2405, P <0.01), suggesting that TPA may cause urinary NH4 + ion excretion increased. CONCLUSIONS: Excessive long-term excretion of NH4 + results in a negative balance of nitrogen in the organism, so it seems that urine NH4 + can be used as an early biological indicator of exposure to TPA.