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目的探讨细胞外信号调节激酶1/2(ERK1/2)在人脑胶质瘤中的表达及其与胶质瘤的发生发展的关系。方法收集具有明确病理分级的胶质瘤标本48例,WHOⅠ~Ⅱ级15例,Ⅲ级21例,Ⅳ级12例;另取8例正常脑组织作正常对照。用免疫组织化学染色检测ERK1/2和磷酸化ERK1/2(p-ERK1/2)表达水平。结果在胶质瘤组织中,ERK1/2和p-ERK1/2表达均增高,且与胶质瘤恶性程度呈正相关;在Ⅲ、Ⅳ级胶质瘤中,ERK1/2和p-ERK1/2表达水平显著强于Ⅰ、Ⅱ级胶质瘤。结论 ERK1/2在胶质瘤组织中表达水平与胶质瘤的恶性程度有关。
Objective To investigate the expression of extracellular signal-regulated kinase 1/2 (ERK1 / 2) in human glioma and its relationship with the occurrence and development of glioma. Methods Forty-eight glioma specimens with definite histological grade were collected. There were 15 cases of gradeⅠ-Ⅱ, 21 cases of grade Ⅲ and 12 cases of grade Ⅳ. Eight normal brain tissues were selected as normal control. The expression of ERK1 / 2 and phosphorylated ERK1 / 2 (p-ERK1 / 2) was detected by immunohistochemistry. Results The expression of ERK1 / 2 and p-ERK1 / 2 in glioma tissues were both increased and positively correlated with the malignant degree of glioma. In grade III and IV gliomas, ERK1 / 2 and p-ERK1 / 2 The expression level was significantly higher than grade Ⅰ and Ⅱ gliomas. Conclusion The expression level of ERK1 / 2 in glioma tissue is related to the malignant degree of glioma.