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目的:调查泌尿生殖道感染患者解脲支原体感染情况及耐药性,指导临床合理应用抗菌药物。方法:采用珠海丽拓发展有限公司生产的支原体培养、鉴定和药敏试剂盒,对610例泌尿生殖道感染患者的分泌物标本进行支原体培养鉴定,同时进行12种抗菌药物的体外药物敏感试验。结果:610例标本中解脲支原体阳性者为212人,阳性率为34.75%;男性患者阳性率为26.68%,女性患者阳性率为59.73%,计数≥104有123人,占总人数的20.16%。抗生素敏感率:诺氟沙星3.3%、红霉素11.32%、氧氟沙星12.26%、强力霉素98.58%、交沙霉素98.58%、美满霉素98.11%。结论:女性患者生殖道解脲支原体感染率显著高于男性患者。解脲支原体对强力霉素、交沙霉素、美满霉素不耐药,而对诺氟沙星、红霉素、氧氟沙星有较高耐药性。解脲支原体的耐药性存在明显地域差异,临床治疗时应参照具体药敏试验结果选择合适药物。
Objective: To investigate Ureaplasma urealyticum infection and drug resistance in patients with genitourinary tract infection and to guide the rational use of antibiotics in clinic. Methods: Mycoplasma culture of 610 cases of genitourinary tract infection was identified by mycoplasma culture, identification and drug sensitivity kit produced by Zhuhai Li Tuo Development Co., Ltd. In vitro drug sensitivity test of 12 kinds of antibacterial drugs was carried out at the same time. Results: The positive rate of Ureaplasma urealyticum was 212 in 610 samples, the positive rate was 34.75%. The positive rate of male patients was 26.68%, the positive rate of female patients was 59.73%, the count ≥ 104 was 123, accounting for 20.16% . Sensitivities of antibiotics: norfloxacin 3.3%, erythromycin 11.32%, ofloxacin 12.26%, doxycycline 98.58%, josamycin 98.58%, minocycline 98.11%. Conclusion: The prevalence of Ureaplasma urealyticum in female patients is significantly higher than that in male patients. Ureaplasma urealyticum doxycycline, josamycin, minocycline drug resistance, and norfloxacin, erythromycin, ofloxacin have higher resistance. Ureaplasma urealyticum drug resistance there is a clear regional differences in clinical treatment should be based on specific drug susceptibility test results to choose the appropriate drug.