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目的开展地中海贫血筛查及G6PD缺乏症检测的干预工程,了解本地区育龄人群中地中海贫血及G6PD缺乏的情况,降低出生缺陷,提高出生人口素质。方法在新婚学校学员中以自愿为原则及前来本站就诊的育龄对象取静脉血共9 126例,用“一管法”红细胞脆性试验进行地中海贫血筛查,用改良G6PD定量比值法进行G6PD缺乏症检测。结果地中海贫血筛查异常者893例,占9.79%,G6PD缺乏症检测出653例,占7.16%。结论地中海贫血筛查及G6PD缺乏症检测方法简便、经济、可接受性高,可及时筛出地中海贫血、G6PD缺乏症高风险夫妇,降低出生缺陷发生,对优生优育和提高人口质量具有积极的意义。
Objective To carry out interventional screening of Thalassemia screening and detection of G6PD deficiency to understand the prevalence of thalassemia and G6PD deficiency among the fertile population of this region, to reduce birth defects and to improve the quality of the birth population. Methods A total of 9 126 venous blood samples were collected from newly married school students based on the principle of voluntariness and the subjects of childbearing age who came to our hospital. Thalassemia screening was conducted using “one tube method” and “red cell fragility test”. The modified G6PD quantitative method G6PD deficiency test. Results 893 cases of abnormal thalassemia screening, accounting for 9.79%, G6PD deficiency detected 653 cases, accounting for 7.16%. Conclusion The method of thalassemia screening and G6PD deficiency detection is simple, economical and acceptable. It can timely screen out thalassemia, couples with high risk of G6PD deficiency and reduce the occurrence of birth defects, and has positive significance to prenatal and postnatal care and population quality improvement .