SIgA是六十年代初Shalicker和Tomas等首先在人体外分泌液中发现的种IgA类抗体 ,其来源、分布、调节和功能有与血清单体IgA差异很大 ,因此形成了SIgA和IgA两个相互独立的抗体体系 ,SIgA存在于呼吸道、唾液、鼻汁、泪以及消化液中 ,担负局部的免疫功能。SIgA的变化与呼吸系统、消化系统的变态反应 ,免疫病患的发生有密切关系。调节SIgA免疫系统有益于临床疾病治疗。 SIgA is a kind of IgA antibody first discovered by human and human exudates such as Shalicker and Tomas in the early 1960s. The origin, distribution, regulation and function of SIgA are very different from that of serum IgA. Therefore, SIgA and IgA are formed Independent antibody system, SIgA is present in the respiratory tract, saliva, nasal juice, tears and digestive juice, responsible for local immune function. SIgA changes and the respiratory system, digestive system allergy, immune disease are closely related. Regulating the SIgA immune system is beneficial for the treatment of clinical conditions.