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为观察急性心肌梗塞（ＡＭＩ）前及其后早期心肌灌注演变特点，对１５例ＡＭＩ患者注射９９ｍＴｃ甲氧基异丁基异腈后开始溶栓，然后采集ＳＰＥＣＴ数据。并于溶栓后第一周及第二周进行心肌显像，分析患者心肌灌注缺血分数。临床显示冠状动脉再通者１０例，未通者３例，不能确定者２例。１５例患者溶栓前与溶栓后第二周缺血分数差异有显著性（ｔ＝２６１，Ｐ＜００５），与溶栓后第一周缺血分数差异无显著性（ｔ＝１７７，Ｐ＞００５）。临床冠状动脉未通的３例患者溶栓前后３次检查均无改善。结果提示：ＡＭＩ溶栓前后连续进行心肌ＳＰＥＣＴ检查，不仅能动态和定量地判断冠状动脉灌注情况，评价溶栓的疗效，估计患者的预后，而且能及时发现和识别高危患者，对判断有无冠状动脉再闭塞也有一定参考价值。
To observe the characteristics of myocardial perfusion before and after acute myocardial infarction (AMI), 15 AMI patients were injected with 99mTc-methoxyisobutylisonitrile and then thrombolysis. SPECT data were collected. Myocardial imaging was performed in the first week and the second week after thrombolysis. Myocardial perfusion ischemia score was analyzed. Clinical coronary recanalization in 10 cases, 3 cases failed, can not be identified in 2 cases. The difference of ischemic score between the 15 patients before thrombolysis and the second week after thrombolysis was significant (t = 261, P <005), and there was no significant difference between the two groups = 177, P> 005). Three patients with uncorrelated coronary arteries had no improvement 3 times before and after thrombolysis. The results suggest that continuous myocardial SPECT before and after thrombolytic therapy can not only judge coronary perfusion dynamically and quantitatively, evaluate the effect of thrombolysis, estimate the prognosis of patients, but also find and identify high-risk patients in time. Artery reocclusion also has some reference value.