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目的调查72株脑膜败血伊丽莎白菌的临床分布及耐药现状,为临床合理应用抗菌药物和预防医院感染提供依据。方法采用Phoenix 100型全自动微生物分析系统对临床分离菌株进行菌种鉴定和药物敏感试验,应用WHONET 5.6软件对数据进行统计分析。结果 72株脑膜败血伊丽莎白菌主要分离自痰液标本(占91.6%),从监护病房分离到57株,占79.1%。药敏结果显示,对米诺环素的耐药率为0,其次为复方新诺明(11.8%)和哌拉西林/他唑巴坦(23.5%)。结论脑膜败血伊丽莎白菌除对米诺环素敏感,复方新诺明和哌拉西林/他唑巴坦较敏感外,对常用抗菌药物表现为严重耐药和多重耐药,应加强监测并根据药敏结果合理选用抗菌药物。
Objective To investigate the clinical distribution and drug resistance status of 72 strains of Meningeal septicemia and provide the basis for rational use of antibiotics and prevention of nosocomial infections. Methods The Phoenix 100 automatic microbiological analysis system was used to identify the strains and drug susceptibility test. The WHONET 5.6 software was used to analyze the data. Results 72 strains of S.aureus were mainly isolated from sputum samples (91.6%), 57 were isolated from the intensive care unit (79.1%). Drug susceptibility results showed that resistance to minocycline was 0, followed by cotrimoxazole (11.8%) and piperacillin / tazobactam (23.5%). Conclusions In addition to being susceptible to minocycline, the compound mechlorethamine and piperacillin / tazobactam are more susceptible to the drug-susceptible and multidrug-resistant common antibacterials and should be monitored and evaluated according to the drug Sensitive results reasonable selection of antimicrobial agents.