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近年的研究证实,肝素对肾脏疾病时的受损肾单位具有保护作用.Olson等发现,肝素能减轻双肾大部分切除大鼠的残存肾脏的病理损害.Diamond等研究也表明,肝素能降低慢性嘌呤霉素肾病大鼠肾小球的系膜增生及局灶性节段性肾小球硬化的发生率.本文在动物实验的基础上,将肝素用于临床肾病综合征的治疗,取得显著效果,现报道如下.
Recent studies confirm that heparin has a protective effect on damaged nephrons in kidney disease.Olson et al found that heparin can reduce the pathological damage of the remnant kidneys of most resected rats.Diamond et al also showed that heparin can reduce chronic Puromycin nephropathy glomerular mesangial hyperplasia and focal segmental glomerulosclerosis incidence in this paper on the basis of animal experiments, the use of heparin for the treatment of clinical nephrotic syndrome, and achieved remarkable results Now reported as follows.