从1935年,文献上有关于镁治疗心律失常的报道,至60年代以后,随着分析技术的发展,对镁的失衡方面进行了更深入的研究。近年来,镁离子与心脏疾患的密切关系日益受到重视。本文就镁治疗心脏疾患的生化基础作一简要综述。镁的正常代谢一、镁在体内的分布:正常成人体内镁的总量为2000mEq/L,约合20～30g,其中50％沉积于骨骼,其余的分布于其它器官和肌肉组织中。骨骼肌含镁量约为血清镁(平均含量为1.6～2.5mEq/L)的 Since 1935, there have been reports in the literature about the treatment of arrhythmias by magnesium. After the 1960s, with the development of analytical techniques, a more in-depth study on the imbalance of magnesium has been conducted. In recent years, the close relationship between magnesium ions and heart disease is paid more and more attention. This article gives a brief overview of the biochemical basis of magnesium in the treatment of heart disease. Magnesium normal metabolism First, the distribution of magnesium in the body: the normal magnesium in the body of the total amount of 2000mEq / L, about 20 ~ 30g, of which 50% deposited in the bones, and the rest in other organs and muscle tissue. Skeletal muscle magnesium content of about serum magnesium (average content of 1.6 ~ 2.5mEq / L)