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研究了剂量分割对ICR/JCL和LACA小鼠的活存率,股骨中骨髓细胞(BMC)和造血干细胞(CFU-S)数,以及CFU-S自我更新能力的影响。剂量分割对小鼠的存活率有明显的影响。在18Gy照射后2个月,接受3.0Gy 6次照射和4. 5 Gy 4次照射的小鼠分别活存40％和15％,但6.0 Gy3次照射小鼠已全数死亡。当总剂量12Gy分割成2—4次照射时,大多数小鼠能活存5个月以上。虽然每根股骨中的BMC数在照后2个月恢复至正常或接近正常水平,但股骨CFU-S含量只相当于同令对照的40％,CFU-S自我更新能力只相当于25％。这种造血残留损伤在照后11个月时仍然存在,在不同的剂量分割组之间未见明显的差别。
The effect of dose-division on the viability of ICR / JCL and LACA mice, the number of bone marrow (BMC) and hematopoietic stem cells (CFU-S) in the femur, and the ability of CFU-S to self-renew were studied. Dose division has a significant impact on the survival rate of mice. At 2 months after irradiation with 18 Gy, 40% and 15% of the mice that received 6 doses of 3.0 Gy and 4 doses of 4 doses of 4 Gy survived, respectively, but all mice that had been irradiated with 6.0 Gy had died in all. When the total dose of 12Gy divided into 2-4 exposure, most mice can survive more than 5 months. Although the number of BMCs in each femur returned to normal or near normal levels 2 months after irradiation, the CFU-S content in the femur was only 40% of that in the control and the self-renewal capacity of CFU-S was only 25%. This hematopoietic residual damage persisted at 11 months of irradiation, with no significant difference between the different dose-divided groups.