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作者探讨了ＮＩＤＤＭ肾病尿ＰＧｓ的来源，变化的机理及意义。结果提示它们主要来自肾脏；肾病早期尿ＴＸＢ２、ＰＧＥ２以及ＰＸＢ２／ＰＧＥ２比值即显著升高，６－酮－ＰＧＦ１ａ无明显变化；ＴＸＢ２升高与肾病恶化有关，可提示肾脏早期受损；ＰＧＥ２升高则属肾病的自身保护反应。这些变化可能与肾小球病损及肾脏血流动力学异常有关。
The authors explored the origin, the mechanism and significance of urinary PGs in patients with NIDDM nephropathy. The results showed that they mainly from the kidney; early urinary TXB2, PGE2 and PXB2 / PGE2 ratio was significantly increased, 6-keto-PGF1a no significant change; TXB2 increased renal damage and renal damage can be prompted early renal damage; PGE2 increased It is a self-protection reaction of kidney disease. These changes may be related to glomerular damage and renal hemodynamic abnormalities.