The microstructure evolution and formability of Ti-10V-2Fe-3Al alloy related to the initial microstructures and processing variables were investigated during hot forming process. The experimental results show that theα-phase growth is controlled by solute diffusion during the heat treatment processes. Four different microstructures were established by combinations of several heat treatments, and Ti-10V-2Fe-3Al alloy shows excellent formability both above and below theβ transus temperature. The alloy possesses low deformation resistance and active restoration mechanism during the deformation. A constitutive equation describing the hot deformation behavior of Ti-10V-2Fe-3Al alloy was obtained. Higher lfow stress was observed for the acicular morphology ofαphase in microstructures with large aspect ratios as compared with that of small aspect ratios. Due to the dynamic recovery in softβphase, and the dynamic recrystallization and breakage of acicularα-phase, lfow softening occurred signiifcantly during deformation. Dynamic recrystallization also occurred especially in the severely deformed regions of forged parts.