本文以~(86)Rb 示踪法观察阿霉素体外对艾氏腹水瘤细胞钠泵转运活性影响。结果:阿霉素体外作用12小时,四种不同浓度(0.2,0.4,0.6,1μg/ml)的抑制率分别为12%,32%,49%,68%;1μg/ml 阿霉素与瘤细胞作用不同时间(0.5,1,6,12小时)的抑制率分别为0%,25%,40%,68%。而阿霉素体外对瘤细胞杀伤和蛋白合成抑制的有效浓度分别为0.4μg/ml 和1μg/ml。提示钠泵活性改变在抗癌药阿霉素作用下,出现较早,抑制程度较重。 In this paper, ~(86)Rb tracer method was used to observe the effect of adriamycin on sodium pump transport activity of Ehrlich ascites tumor cells in vitro. RESULTS: Doxorubicin was treated for 12 hours in vitro. The inhibition rates at four different concentrations (0.2, 0.4, 0.6, and 1 μg/ml) were 12%, 32%, 49%, and 68%, respectively; 1 μg/ml adriamycin and tumor The inhibitory rates of cell action at different time (0.5, 1, 6, 12 hours) were 0%, 25%, 40%, and 68%, respectively. The effective concentration of doxorubicin in vitro for tumor cell killing and protein synthesis inhibition was 0.4 μg/ml and 1 μg/ml, respectively. It suggested that the activity of sodium pump changed earlier under the effect of anticancer drug doxorubicin, and the degree of inhibition was heavier.