The Suzhou Creek is a seriously polluted tidal river in Shanghai. The Suzhou Creek Rehabilitation Project was launched in 1998, and the total investment will surpass 10 billion yuan RMB. It is important to assess the effectiveness of the project and ascertain its targets. In this study, by analyzing the achievements of Suzhou Creek Rehabilitation Project (Stage I) and its remaining problems, the main tasks of the Project Stage II are proposed. These works are wastewater interception, sediment dredging, bidirectional water diversion, and reconstruction of municipal pump stations. The water quality model established with USEPAs WASP is employed to analyze the quantitative targets of the Project Stage II. In the Project Stage II, the water quality of mainstream and tributaries will be improved continuously, the valus of CODCr, BOD5, DO in the mainstream will steadily attain Class IV according to the National Surface Water Quality Standard, and the ecological environment of Suzhou Creek with continuously recover.