为了解乙型肝炎血源疫苗皮内接种的持久效果，选ＨＢｓＡｇ、抗－ＨＢｓ和抗－ＨＢｃ均（－）的９～１１岁儿童１０３名，随机分成４组，分别皮内接种１μｇ×４和３μｇ×４（均按０，１，２，５月程序）和肌肉接种１０μｇ×３和３０μｇ×３（各按０，１，２月程序）。首针后４８月时，１μｇ、３μｇ、１０μｇ和３０μｇ组抗－ＨＢｓ≥１０ｍＩＵ／ｍＩ者各为６９．２％，８０．０％、９２．３％和８１．８％；ＧＭＴ则为１４．５，７９．０，４４．８和７０．９ｍＩＵ／ｍｌ，３μｇ×４皮内免疫的近期和远期效果与肌肉组３０μｇ×３相似，宜于某些人群采用 To understand the long-lasting effect of intradermal vaccination of Hepatitis B virus vaccine, 103 children aged 9 to 11 years with HBsAg, anti-HBs and anti-HBc (-) were randomly divided into 4 groups and inoculated intradermally with 1 μg × 4 And 3 μg × 4 (both 0, 1, 2 and 5 month programs) and intramuscular inoculation of 10 μg × 3 and 30 μg × 3 (each 0, 1, 2 month program). At 48 months after the first injection, 69.2%, 80.0%, 92.3% and 81.8% of 1μg, 3μg, 10μg and 30μg of anti-HBs ≧ 10mIU / mI each had a GMT of 14. The short-term and long-term effects of 5, 79.0, 44.8 and 70.9 mIU / ml, 3 μg × 4 intradermal immunization were similar to those of muscle group 30 μg × 3,