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目的建立同步测定麝香追风膏中桉油精、樟脑、薄荷脑、冰片(龙脑和异龙脑)、水杨酸甲酯、桂皮醛和丁香酚等7种成分含量的气相色谱方法。方法采用气相色谱法,HP-INNOWAX毛细管色谱柱,氮气为载气,FID检测器,升温程序为80℃保持5 min,60℃/min升温至150℃保持5 min,80℃/min升温至200℃保持2 min,内标法测定样品中7种成分的含量。结果麝香追风膏中7种成分及内标物萘在同一色谱条件下获得良好分离。回收率分别为96.23%(RSD=2.48%)、100.31%(RSD=0.23%)、96.76%(RSD=0.76%)、96.90%(RSD=1.39%)、98.52%(RSD=1.57%)、96.32%(RSD=2.01%)和103.31%(RSD=2.12%)。采用此法对3批样品进行含量测定,均取得了满意的结果。结论该方法简便、准确,分离度好,可用于控制麝香追风膏的质量。
OBJECTIVE To establish a gas chromatographic method for the simultaneous determination of eucalyptol, camphor, menthol, borneol (isoborneol and isoborneol), methyl salicylate, cinnamaldehyde and eugenol in Musk chaige cream. Methods Gas chromatography, HP-INNOWAX capillary column, nitrogen as carrier gas and FID detector were used. The temperature was kept at 80 ℃ for 5 min, the temperature was increased from 60 ℃ / min to 150 ℃ for 5 min and the temperature was raised to 200 at 80 ℃ / min ℃ for 2 min, and the content of seven components in the sample was determined by internal standard method. Results The results showed that the seven components in the musk-chai changfeng cream and the internal standard naphthalene were well separated under the same chromatographic conditions. The recoveries were 96.23% (RSD = 2.48%), 100.31% (RSD = 0.23%), 96.76% (RSD = 0.76%), 96.90% (RSD = 1.39%), 98.52% % (RSD = 2.01%) and 103.31% (RSD = 2.12%). Using this method for three batches of samples for determination, have achieved satisfactory results. Conclusion The method is simple, accurate, good resolution, and can be used to control the quality of musk chai cream.