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子宫内膜异位症(Endometriosis,EMs)是好发于育龄期妇女的良性疾病[1],大量新生血管的生成可能是EMs发病的关键[2]。缺氧诱导因子-1(hypoxia-inducible factor-1,HIF-1)是缺氧条件下存在于人体和哺乳动物细胞内的一种转录因子,HIF-1α是HIF-1的亚基,在肿瘤新生血管的形成中起着重要作用。江丽霞等[3]报道,HIF-1α与宫颈癌临床病理特征关系密切,呈显著正相关。1 HIF-1α的结构HIF-1最先由Semenza等[4]于1992年作为被低氧诱导的、连接在红细胞生成素基因低氧反应元件(hypoxia response element,HRE)上的一个核因子被发现。HIF-1是一个转录因子。HIF-1是由α和β两个
Endometriosis (EMs) is a benign disease in women of childbearing age [1], a large number of new blood vessels may be the key to the pathogenesis of EMs [2]. Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that exists in human and mammalian cells under hypoxia. HIF-1α is a subunit of HIF-1, Neovascularization plays an important role. Jiang Lixia et al [3] reported that HIF-1α and cervical cancer are closely related to clinicopathological features, was significantly positive correlation. 1 The structure of HIF-1α HIF-1 was firstly induced by hypoxia in Semenza et al [4] in 1992 as a nuclear factor linked to hypoxia response element (HRE) of erythropoietin Find. HIF-1 is a transcription factor. HIF-1 is composed of both α and β