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目的:探索可客观反映职业性苯危害的灵敏指标。方法:测定苯作业车间空气苯浓度和33名苯作业工人及4名非苯作业工人志愿者苯接触后呼出苯浓度、血苯含量及尿酚排出量,并进行相关性分析。结果:空气苯浓度(4.5~348mg/m3)与血苯含量呈明显正相关(P<0.05);血苯含量与尿酚排出量呈非常显著正相关(P<0.01)。结论:在低浓度苯接触时,血苯是一个与毒性相关联的特异性敏感苯吸收指标;尿酚排出量可用作高浓度苯接触工人的生物监测指标。
Objective: To explore sensitive indicators that objectively reflect the hazard of occupational benzene. Methods: The concentrations of benzene, blood benzene and urinary phenol in the air of benzene workshop and the benzene of 33 benzene workers and 4 non-benzene workers were measured and the correlation was analyzed. Results: The concentration of benzene in air (4.5 ~ 348mg / m3) was positively correlated with the content of blood benzene (P <0.05). There was a significant positive correlation between blood benzene and urinary phenol output (P <0.01) . CONCLUSIONS: Blood benzene is a specific sensitive indicator of benzene absorption associated with toxicity at low concentrations of benzene exposure; urinary phenol excretion can be used as a bio-monitoring indicator of high-concentration benzene exposure workers.