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目的探讨增殖细胞核抗原（ＰＣＮＡ）与胃癌生物学行为的关系。方法应用流式细胞术，对６８例胃癌及癌旁组织细胞中ＰＣＮＡ的表达进行了检测。结果ＰＣＮＡ在胃癌中的表达明显高于正常胃粘膜及癌旁组织；ＰＣＮＡ指数与胃癌分化程度及肿瘤浸润深度有关（Ｐ＜０．０５）。结论检测ＰＣＮＡ的表达有助于发现早期癌变及判断胃癌的生物学特性。
Objective To investigate the relationship between proliferating cell nuclear antigen (PCNA) and biological behavior of gastric cancer. Methods Flow cytometry was used to detect the expression of PCNA in 68 cases of gastric cancer and paracancerous tissues. Results The expression of PCNA in gastric cancer was significantly higher than that in normal gastric mucosa and adjacent tissues. The PCNA index was related to the degree of differentiation of gastric cancer and the depth of tumor invasion (P<0.05). Conclusion The detection of PCNA expression is helpful to discover early canceration and determine the biological characteristics of gastric cancer.