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为探讨肺癌病人放疗前后血清血管内皮生长因子(VEGF)水平变化与预后的关系,采用双抗体夹心ELISA法检测33例肺癌病人放疗前后血清VEGF的水平,与20名健康人作对照。结果显示,放疗前肺癌组血清VEGF水平较对照组明显升高,差异有非常显著意义(P<0.01);放疗结束时及放疗后3～6个月血清VEGF水平明显下降(P<0.01)。放疗后有6例血清VEGF含量持续高水平状态,均在6个月内出现复发或转移。结论:血清VEGF水平动态变化,可为肺癌病人病情监测及预后判断提供观察指标。
To explore the relationship between serum vascular endothelial growth factor (VEGF) levels and prognosis of patients with lung cancer before and after radiotherapy, serum VEGF levels in 33 patients with lung cancer before and after radiotherapy were measured by double-antibody sandwich ELISA and compared with 20 healthy subjects. The results showed that serum VEGF levels in the lung cancer group before radiotherapy were significantly higher than those in the control group (P<0.01), and serum VEGF levels were significantly decreased at the end of radiotherapy and 3 to 6 months after radiotherapy (P<0.01). After radiotherapy, serum VEGF levels in 6 patients continued to be high, and recurrence or metastasis occurred within 6 months. Conclusion: The dynamic changes of serum VEGF levels can provide indicators for the monitoring of lung cancer patients’ condition and prognosis.